Modeling Early Intervention in Schizophrenia: Role of BDNF

Grant number: 1044777 | Funding period: 2013 - 2015

Completed

Abstract

Schizophrenia is a major burden on sufferers and society at large. Currently available treatments are only partially effective and often associated with significant side effects. This project will explore the neurobiological mechanisms of early preventative treatments in schizophrenia using a 'two hit' developmental mouse model. The results could have important clinical implcations for preventative treatment options.

Related publications (2)

Sex-dependent effects of environmental enrichment on spatial memory and brain-derived neurotrophic factor (BDNF) signaling in a developmental “two-hit” mouse model combining bdnf haploinsufficiency and chronic glucocorticoid stimulation

AM Grech, U Ratnayake, AJ Hannan, M van den Buuse, RA Hill

2018-10-09

Neurodevelopmental disorders are thought to be caused by a combination of adverse genetic and environmental insults. The “two-hit”..

Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice

NC Jones, M Hudson, J Foreman, G Rind, R Hill, EE Manning, M van den Buuse

2018-10-01

Schizophrenia is a complex psychiatric disorder with a heterogeneous aetiology involving genetic and environmental factors. Defici..

University of Melbourne Researchers

Anthony Hannan